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Target intelligence / Profile preview
Selenoprotein H (SELENOH)
- Target
- SELENOH
- Molecular classification
- Selenoprotein, Oxidoreductase, DNA-binding protein, SelWTH family
01
Overview
Selenoprotein H (SELENOH) is a nucleolar protein with oxidoreductase and DNA-binding activities. It plays a crucial role in maintaining redox homeostasis, protecting cells from oxidative stress, and regulating mitochondrial biogenesis. SELENOH is highly responsive to dietary selenium and its deficiency is linked to increased susceptibility to oxidative damage and developmental defects. It also has roles in genome maintenance and tumor suppression. SELENOH expression is altered in some cancers.
02
Mechanism of action
Not applicable, SELENOH is a target, not a drug.
03
Biological functions
Redox regulationAntioxidant activityGlutathione peroxidase activityDNA bindingMitochondrial biogenesis activationRegulation of gene expression
04
Disease associations
CancerOxidative stress-related diseasesDevelopmental defects
05
Safety considerations
Selenium depletion reduces SELENOH expression and function.Overexpression in certain cancers.
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