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Serine beta-lactamase-like protein LACTB, mitochondrial
- Molecular classification
- Enzyme, Serine Protease
01
Overview
LACTB is a serine beta-lactamase-like protein localized in the mitochondrial intermembrane space. It regulates mitochondrial lipid metabolism and functions as a tumor suppressor. Overexpression is linked to obesity phenotypes, and it plays a role in cancer by modulating lipid metabolism, interacting with p53, and influencing responses to chemotherapy. It also contributes to mitochondrial organization through filament formation.
- Other names
- G24MRPL56lactamase beta[1]
02
Mechanism of action
Acts as an active-site serine protease regulating mitochondrial lipid metabolism; Directly binds to p53’s C-terminal region, preventing its degradation; Modulates responses to chemotherapeutic agents such as oxaliplatin by decreasing glucose uptake/ATP synthesis, inducing DNA damage, inhibiting autophagy, promoting apoptosis via caspase-independent pathways
03
Biological functions
Regulation of mitochondrial lipid metabolismTumor suppressionRegulation of metabolic circuitryModulation of p53 stability/activityDNA repairApoptosisCell cycle arrestMitochondrial organization
04
Disease associations
ObesityBreast cancerColorectal cancer
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