Serotonin 5-HT2 Receptor Family (including 5-HT2A, 5-HT2B, and 5-HT2C subtypes) (5-HT2 Receptor Family)

The serotonin (5-HT) 2 receptor family, including 5-HT2A, 5-HT2B and 5-HT2C subtypes, are G protein-coupled receptors that mediate the effects of serotonin in the central and peripheral nervous systems. Activation of these receptors primarily couples via Gq/11 proteins, leading to activation of phospholipase C (PLC) and subsequent increases in intracellular calcium and activation of protein kinase C. These receptors are widely distributed throughout the brain and are involved in a variety of physiological functions, including mood regulation, cognition, and sensory perception. They are also targets for numerous drugs, including antipsychotics, antidepressants, and hallucinogens. Receptor levels can be regulated by developmental stage or pharmacological intervention.

Other names

5-Hydroxytryptamine Receptor 25-HT2A Receptor5-HT2B Receptor5-HT2C ReceptorSerotonin Receptor 2

Agonism or antagonism of 5-HT2 receptors, leading to modulation of downstream signaling pathways involving Gq/11 proteins, phospholipase C (PLC), inositol trisphosphate (IP3), diacylglycerol (DAG), protein kinase C (PKC), and intracellular calcium levels.