Serotonin transporter, Norepinephrine transporter, and Dopamine transporter (SERT, NET, DAT)

The serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) are three closely related proteins belonging to the solute carrier family 6 (SLC6) of Na^+/Cl^−^-dependent neuronal membrane transporters. They mediate the rapid reuptake of their respective monoamine neurotransmitters—serotonin (5-HT), norepinephrine (NE), and dopamine (DA)—from the synaptic cleft back into presynaptic neurons, thereby terminating neurotransmission and recycling neurotransmitter for vesicular storage or degradation. These transporters are expressed throughout the central and peripheral nervous systems and play vital roles in mood regulation, cognitive function, and motor control. They are considered primary pharmacological targets for antidepressants, psychostimulants, and drugs of abuse, and their dysfunction is implicated in a range of neuropsychiatric and neurodegenerative diseases.

Other names

Serotonin transporter (also: 5-HT transporter, 5-HTT; gene: SLC6A4)Norepinephrine transporter (also: noradrenaline transporter, NET; gene: SLC6A2)Dopamine transporter (also: DAT; gene: SLC6A3)Collectively: monoamine transporters, Na^+/Cl^−^-dependent monoamine transporters

Competitive inhibition or blockade of neurotransmitter reuptake (SSRIs, SNRIs, TCAs, cocaine, methylphenidate) Substrate reversal or release (amphetamines, MDMA) Modulation of transporter trafficking and phosphorylation