Serotonin transporter, Norepinephrine transporter, Dopamine transporter

Monoamine transporters—including the **serotonin transporter (SERT)**, **norepinephrine transporter (NET)**, and **dopamine transporter (DAT)**—are integral membrane proteins of the SLC6 family that mediate the high-affinity reuptake of their respective monoamine neurotransmitters from the synaptic cleft into the presynaptic neuron, thereby terminating neurotransmitter signaling and regulating synaptic monoamine levels[2][4][5][8]. Each transporter consists of 12 transmembrane helices and relies on sodium and chloride co-transport to drive neurotransmitter uptake against a concentration gradient[2][4][5][7][8]. Their modulation by drugs underlies the efficacy of many antidepressants, psychostimulants, and analgesics, while their dysfunction is implicated in psychiatric and neurological disorders[3][4][8].

Other names

5-HT transporterSERTNoradrenaline transporterNETDATdopamine active transporterMonoamine transportersMATs

Inhibition of neurotransmitter reuptake, increasing extracellular monoamine levels in the synaptic cleft\nCompetitive and noncompetitive inhibition\nSubstrate translocation and reverse transport (depending on the drug)\nModulation of transporter conformation