Serotonin transporter; Norepinephrine transporter (SERT (for serotonin transporter); NET (for norepinephrine transporter))

The serotonin transporter (SERT, encoded by SLC6A4) and the norepinephrine transporter (NET, also called noradrenaline transporter, encoded by SLC6A2) are integral membrane proteins of the solute carrier family 6. They are monoamine transporters responsible for the reuptake of serotonin and norepinephrine, respectively, from the synaptic cleft back into presynaptic neurons, thus terminating neurotransmitter action and regulating neurotransmitter levels in the central nervous system. Both are important therapeutic targets in the treatment of depression, anxiety disorders, ADHD, and other neuropsychiatric and neurological illnesses. Drugs targeting these transporters can increase neurotransmitter concentrations in the synaptic cleft, thereby enhancing their effects. The activity and regulation of these transporters are critical for normal synaptic signaling, and genetic variability may affect disease susceptibility and treatment response[1][2][3][4][5][6]. **Note:** - The original query asked for "Serotonin Transporter and Noradrenaline Transporter" as a single target. However, these are distinct proteins, each encoded by different genes, with different primary ligands (serotonin vs. norepinephrine) and biological roles. Therefore, the entry as a single combined target is *incorrect* for most structured pharmacological reference systems. These should be treated as two separate canonical entries: Serotonin transporter (SERT) and Norepinephrine transporter (NET). - For structured use, split or provide separate data for each[1][2][3][4][6].

Other names

SERT5-HTTSolute carrier family 6 member 4 (for serotonin transporter)NETNATSolute carrier family 6 member 2 (for norepinephrine transporter)

Inhibition of serotonin reuptake (SERT blockers increase synaptic serotonin) [3] Inhibition of norepinephrine reuptake (NET blockers increase synaptic norepinephrine) [1][2] Dual inhibition (SNRIs inhibit both SERT and NET) [6] Modulation of transporter expression or function through phosphorylation or drug exposure [5]