Serpin peptidase inhibitor, clade B (ovalbumin), member 10 (SERPINB10)

Serpin peptidase inhibitor, clade B (ovalbumin), member 10 (commonly abbreviated as SERPINB10 or known as Serpin B10/Bomapin/PI-10) is a member of the intracellular serpin (serine protease inhibitor) family that regulates protease activity, mainly during hematopoiesis and in response to inflammatory and apoptotic stimuli[1][3][4][7][13]. SERPINB10 is found in the cytoplasm and nucleus without signal peptide targeting, and its primary functions include modulation of cell survival and response to stress such as UV damage, regulation of apoptosis, and influence on DNA repair processes[2][13]. SERPINB10 has context-dependent roles in cancer; for example, it is upregulated in some tumors (lung) and downregulated in others (breast), while specific genetic variants are linked to increased prostate cancer risk[2][3][4]. It may also contribute to inflammatory disorders, such as allergic airway inflammation, by influencing cytokine and chemokine expression[14]. There are no currently approved drugs that directly target SERPINB10, and its main therapeutic relevance is as a disease-associated modulator, potential biomarker, or candidate for engineered inhibitor/activator design within the broad serpin superfamily[5][8][12].

Other names

Serpin B10BomapinPI10PI-10Peptidase inhibitor 10Protease inhibitor 10 (ovalbumin type)Serpin family B member 10