SH3 domain-containing GRB2-like protein 3 (Endophilin-A3) (SH3GL3)

SH3 domain-containing GRB2-like protein 3 (Endophilin-A3, SH3GL3) is a member of the endophilin A subfamily, characterized by the presence of both an SH3 domain and a BAR domain, granting the ability to mediate protein–protein interactions and induce membrane curvature, respectively[1][2][3][5]. Endophilin-A3 is mainly expressed in the brain and testicular tissues and is involved in clathrin-mediated endocytosis, where it helps recruit and organize other proteins at sites of high membrane curvature and regulates synaptic vesicle formation and recycling[1][2][3][5]. It is implicated in central nervous system development, and altered expression or function has been associated with neurodegenerative diseases such as Huntington disease and ALS/FTD, as well as a poor prognosis in advanced colorectal cancer[1][2][4][5]. Although it participates in pathways relevant to cellular growth and signaling, at present, Endophilin-A3/SH3GL3 itself is not considered a direct therapeutic target nor are there known drugs or biomarkers for clinical targeting.

Other names

Endophilin-A3Endophilin 3CNSA3SH3D2CSH3P13EEN-B2HsT19371SH3 domain protein 2CSH3 domain-containing GRB2-like 3