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Target intelligence / Profile preview
Sialate:O-sulfotransferase 1 (WSCD1)
- Target
- WSCD1
- Molecular classification
- Enzyme
01
Overview
Sialate:O-sulfotransferase 1 (WSCD1) is a protein-coding gene located on human chromosome 17. It encodes an enzyme that catalyzes the addition of a sulfate group to the 8-position of sialic acid residues in sialic acid–containing glycans (8-O-sulfation) through use of the cofactor 3'-phosphoadenosine 5'-phosphosulfate (PAPS)[1][3]. WSCD1 shows specificity for glycolipids, notably GM1 gangliosides, and is predicted to be localized to the Golgi membrane[2][3][4][5]. Dysregulation or mutation of WSCD1 has been associated with several diseases, including colorectal cancer, glioblastoma, Alzheimer disease, migraine, and syndromic intellectual disability[1][2][3]. There is no current evidence for existing drugs directly targeting WSCD1 or its use as a clinical biomarker, but its role in glycosylation and disease suggests emerging interest as a molecular target.
- Other names
- WSC domain containing 1KIAA0523WSCD1WSC domain-containing protein 1Sialate:O-sulfotransferase 1
02
Biological functions
Sulfation of sialic acid glycansGlycolipid modificationLikely involvement in cellular processes reliant on glycosylation patterns
03
Disease associations
Cancer (including colorectal cancer and glioblastoma)Neurodegenerative diseases (Alzheimer disease)Migraine disorderSyndromic X-linked intellectual disability, Nascimento type
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