Signal transducer and activator of transcription 3 (Stat3) mRNA (Stat3 mRNA)

Signal transducer and activator of transcription 3 (Stat3) mRNA is the messenger RNA transcript that encodes the Stat3 protein, a pivotal transcription factor in the JAK-STAT signaling pathway (UniProt P42227). In murine models and human biology, Stat3 is essential for mediating cellular responses to cytokines like interleukin-6 (IL-6) and various growth factors, influencing processes such as cell proliferation, survival, and immune regulation (PubMed: 23548215). Pathologically, the overactivation of the Stat3 pathway is linked to the progression of numerous malignancies and chronic inflammatory conditions, where it facilitates tumor evasion and pro-inflammatory gene expression (PubMed: 21734241). Therapeutic targeting of Stat3 mRNA, primarily through antisense oligonucleotides (ASOs) like Danvatirsen (AZD9150) or murine-specific analogs like ISIS 348574, aims to induce RNase H-mediated degradation of the transcript to prevent protein translation (PubMed: 25918253). This approach offers a method to downregulate a traditionally "undruggable" transcription factor, though it requires careful monitoring for side effects such as thrombocytopenia and liver enzyme elevations (PubMed: 29439119).

Other names

Stat3AprfAcute-phase response factor mRNASignal transducer and activator of transcription 3 (acute-phase response factor)

Antisense oligonucleotide-mediated RNase H-dependent degradation of mRNA, leading to reduced protein translation.