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Target intelligence / Profile preview
Signaling Lymphocytic Activation Molecule (SLAM) Family Receptors (SLAMFs)
- Target
- SLAMFs
- Molecular classification
- Receptor, Immunoglobulin superfamily, Type I transmembrane glycoprotein
01
Overview
The Signaling Lymphocytic Activation Molecule (SLAM) family receptors (SLAMFs) are a group of nine type I transmembrane glycoproteins belonging to the immunoglobulin superfamily. They play critical roles in immune cell signaling, development, and function, regulating various aspects of immune responses including cytotoxicity, humoral immunity, cell adhesion, and cytokine production. Their function is largely controlled by interaction with intracellular adaptor proteins from the SAP family, leading to either activating or inhibitory signaling pathways. Due to their central role in immunity, SLAMFs are attractive therapeutic targets for modulating immune responses in autoimmunity or cancer.
- Other names
- SLAM family receptorsSLAM receptorsCD150 family
02
Mechanism of action
Modulation of immune responses through agonism or antagonism of SLAMF receptors, influencing downstream signaling pathways via SAP family adaptors and Src-family kinases or SHP phosphatases.
03
Biological functions
Immune regulationCytotoxicityHumoral immunityCell adhesionCytokine productionSignal transductionInnate defense
04
Disease associations
ImmunodeficiencyAutoimmunityCancerInfection
05
Safety considerations
Potential for immune-related adverse eventsRisk of exacerbating autoimmune conditionsOff-target effects due to broad expression on hematopoietic cells
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