Sirtuin 6 mRNA 3'-untranslated region (SIRT6 mRNA 3'-UTR) (SIRT6 mRNA 3'-UTR)

The Sirtuin 6 (SIRT6) mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the SIRT6 transcript that governs the stability and translation efficiency of the SIRT6 protein (PMID: 21655084). SIRT6 itself is a member of the sirtuin family of NAD+-dependent deacetylases and is involved in essential biological processes such as DNA repair, telomere maintenance, glucose metabolism, and longevity (PMID: 22367541). The 3'-UTR contains binding sites for various microRNAs (miRNAs) and RNA-binding proteins, which can suppress SIRT6 expression under specific physiological or pathological conditions (PMID: 24631215). For instance, miR-33 and miR-34a have been shown to target this region, leading to reduced SIRT6 levels and contributing to metabolic dysfunction or cellular senescence (PMID: 21655084, PMID: 24631215). Targeting the SIRT6 mRNA 3'-UTR with antisense oligonucleotides or miRNA mimics/antagomirs represents a therapeutic strategy to modulate SIRT6 levels in diseases like cancer, where SIRT6 can act as either a tumor suppressor or promoter depending on the context (PMID: 23245941). Furthermore, the 3'-UTR's role in post-transcriptional regulation makes it a focal point for research into aging and age-related diseases. Therapeutic interventions aiming to stabilize SIRT6 mRNA by blocking miRNA binding sites are currently being explored to enhance its protective effects. Overall, the SIRT6 mRNA 3'-UTR serves as a pivotal node for controlling the dosage of this multi-functional protein in human health and disease.

Other names

SIRT6 3'-UTRSirtuin 6 3'-UTRSIRT6 3'-untranslated region

Modulation of SIRT6 protein expression through RNA interference or by blocking the binding of regulatory microRNAs and RNA-binding proteins to the 3'-UTR.