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Target intelligence / Profile preview
Smoothened, frizzled class receptor (SMO)
- Target
- SMO
- Molecular classification
- G protein-coupled receptor, GPCR, Frizzled/Smoothened family receptor, Class F GPCR
01
Overview
Smoothened (SMO) is a Class F GPCR and a key component of the Hedgehog signaling pathway, essential for development and tissue homeostasis. It is inhibited by Patched (PTCH1) in the absence of Hedgehog ligands and activated upon ligand binding to PTCH1. Aberrant SMO activation is implicated in several cancers, particularly basal cell carcinoma and medulloblastoma, making it a therapeutic target. However, resistance to SMO inhibitors is a growing concern.
- Other names
- Smoothened receptorSMO receptor
02
Mechanism of action
Upon Hedgehog ligand binding to PTCH1, SMO is activated and interacts with Gi proteins to propagate downstream signaling, regulating gene expression.
03
Biological functions
Signal transductionEmbryonic developmentTissue homeostasisCellular differentiationHedgehog signaling pathway regulation
04
Disease associations
CancerBasal cell carcinomaMedulloblastomaDevelopmental disorders
05
Safety considerations
Resistance to SMO inhibitors (e.g., vismodegib)Teratogenicity of some SMO inhibitors (e.g., cyclopamine)
06
Interacting drugs
SAG
2 more in the full profile.
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