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Target intelligence / Profile preview
Sodium Channel (Neuronal) (VGSC)
- Target
- VGSC
- Molecular classification
- Ion channel, Voltage-gated ion channel
01
Overview
Neuronal sodium channels are integral membrane proteins that form ion channels, specifically conducting sodium ions (Na⁺) through the cell membrane of neurons. These channels are essential for generating and propagating action potentials, which underlie neuronal excitability and communication within the nervous system.
- Other names
- Voltage-gated sodium channelNaV channelNeuronal sodium channelNALCN (Sodium Leak Channel)
02
Mechanism of action
Block sodium channel conductance, alter channel gating kinetics
03
Biological functions
Action potential generationAction potential propagationNeuronal excitabilityResting membrane potential regulation
04
Disease associations
EpilepsyNeuropathic painBrain tumorsNeural traumaMultiple sclerosisChronic painMigraine
05
Safety considerations
ArrhythmiaSeizuresCardiovascular effectsNeurological effects
06
Interacting drugs
Lidocaine
5 more in the full profile.
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