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Sodium channel protein (cardiac) (NaV1.5)
- Target
- NaV1.5
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The cardiac sodium channel protein (NaV1.5), encoded by the SCN5A gene, is a voltage-gated transmembrane protein essential for the rapid upstroke of the cardiac action potential and fast impulse conduction through heart tissue. It initiates cellular depolarization, which triggers and propagates electrical signals necessary for coordinated heart contractions. Mutations or dysfunctions in SCN5A/NaV1.5 can cause various inherited arrhythmia syndromes.
- Other names
- Cardiac sodium channelSCN5ASodium voltage-gated channel alpha subunit 5hH1
02
Mechanism of action
Block or modulate NaV1.5 activity; inhibit late/persistent INa component
03
Biological functions
Membrane depolarizationAction potential propagationRegulation of heart rateCardiac muscle contraction
04
Disease associations
ArrhythmiaBrugada syndromeLong QT syndromeCardiac conduction diseaseHeart failureSudden cardiac death
05
Safety considerations
Pro-arrhythmic effects of some antiarrhythmic drugsQT prolongationDrug-drug interactions
06
Interacting drugs
Antiarrhythmic drugs (e.g., lidocaine, flecainide)
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