Sodium Channel Protein (late INa) (late INa)

The sodium channel protein responsible for the late sodium current (late INa) is a voltage-gated sodium channel, primarily found in excitable tissues such as nerve, muscle, and heart. It mediates fast depolarization during action potentials by allowing Na+ influx when activated by membrane depolarization. Late INa plays critical roles in cardiac electrophysiology: it contributes to action potential duration and arrhythmogenesis if abnormally increased.

Other names

Late Sodium CurrentPersistent Sodium CurrentVoltage-gated sodium channel (late)Nav1.5 (late)SCN5A (late)

Inhibition of late sodium current, reducing intracellular sodium overload and preventing delayed repolarization.