Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sodium-Hydrogen Exchanger 3 (NHE3)
- Target
- NHE3
- Molecular classification
- Membrane transporter protein, Antiporter
01
Overview
Sodium-Hydrogen Exchanger 3 (NHE3), encoded by the SLC9A3 gene, is a membrane transporter protein that exchanges intracellular hydrogen ions (H⁺) for extracellular sodium ions (Na⁺) across the plasma membrane. It plays a crucial role in maintaining sodium balance, fluid absorption, intracellular pH regulation, and acid-base homeostasis, primarily in the kidney proximal tubule and intestinal epithelial cells. As such, NHE3 is a therapeutic target for diseases such as hypertension, chronic kidney disease, and gastrointestinal disorders.
- Other names
- NHE-3Sodium–hydrogen antiporter 3Solute carrier family 9 member A3SLC9A3DIAR8
02
Mechanism of action
Inhibition of Na+/H+ exchange, modulation of systemic sodium levels
03
Biological functions
Maintains sodium balance and fluid absorptionRegulates intracellular pHAcid–base homeostasisBicarbonate productionWater absorptionNutrient uptake (HCO₃⁻, NH₄⁺, short-chain fatty acids)
04
Disease associations
HypertensionChronic kidney diseaseCongestive heart failureElectrolyte disturbancesHyperphosphatemiaOsmotic diarrhea
05
Safety considerations
Potential for electrolyte imbalancesEffects on blood pressure
Beyond the preview
Go deeper on Sodium-Hydrogen Exchanger 3 (NHE3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sodium-Hydrogen Exchanger 3 (NHE3).