Target intelligence / Profile preview

Sodium Ion (Peritoneal Diffusion) (None)

Target: None
Molecular classification: Electrolyte, Small molecule

Overview

Sodium ion (Na⁺) is a key extracellular electrolyte involved in fluid and electrolyte balance. In peritoneal dialysis, sodium moves across the peritoneal membrane via diffusion and convection. The rate of sodium transport is influenced by dialysate composition (sodium, glucose, icodextrin) and the characteristics of the peritoneal membrane. Clinicians adjust dialysate composition to optimize sodium and fluid removal while minimizing complications.

Mechanism of action

Movement across the peritoneal membrane driven by concentration gradients (diffusion) and osmotic gradients (convection/ultrafiltration).

Biological functions

Fluid balanceElectrolyte balanceOsmotic regulationTransmembrane transport

Disease associations

Kidney failureFluid overloadElectrolyte imbalanceHyponatremiaHypernatremia

Safety considerations

HyponatremiaHypernatremiaFluid overloadDehydrationPeritoneal membrane dysfunction/fibrosis

Interacting drugs

Peritoneal dialysis solutions (containing varying sodium concentrations)

2 more in the full profile.

Biomarkers

Dialysate sodium concentrationPlasma sodium concentrationUltrafiltration volumeMass transfer area coefficient (MTAC)Permeability-surface area product (PS)

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