Solute carrier family 1 member 5 mRNA 3' untranslated region (SLC1A5 mRNA 3'UTR) (SLC1A5 mRNA 3'UTR)

The Solute carrier family 1 member 5 (SLC1A5) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the messenger RNA encoding the ASCT2 protein, a primary transporter for glutamine (PMID: 29343437). In many malignancies, SLC1A5 is overexpressed to meet the high metabolic demand for glutamine, a phenomenon known as glutamine addiction (PMID: 30104711). The 3'UTR contains specific binding sites for microRNAs (miRNAs) such as miR-137 and miR-122, which control the stability and translation efficiency of the SLC1A5 transcript (PMID: 28656230, PMID: 25605236). Therapeutic strategies targeting this region, such as miRNA mimics or antisense oligonucleotides, aim to downregulate SLC1A5 expression, thereby starving cancer cells of essential nutrients and inhibiting tumor progression (PMID: 31439341). Because SLC1A5 is a key driver of metabolic reprogramming in cancer, its mRNA 3'UTR represents a promising target for precision oncology and RNA-targeted drug development (UniProt P43007).

Other names

ASCT2 mRNA 3'UTRNeutral amino acid transporter B(0) mRNA 3'UTRSLC1A5 3'-untranslated regionATB(0) mRNA 3'UTR

Binding to the 3' untranslated region to induce mRNA degradation or inhibit translation, thereby reducing the expression of the SLC1A5 protein and limiting glutamine uptake in cancer cells.