Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10 (GLUT10))

Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10, also known as GLUT10) is a membrane protein and member of the class III facilitative glucose transporter family. SLC2A10 primarily facilitates the transport of glucose and dehydroascorbic acid (oxidized vitamin C) across cell membranes, with broad tissue expression including heart, lung, brain, liver, skeletal muscle, pancreas, placenta, and kidney. SLC2A10 is structurally distinct from other glucose transporters and is associated with critical biological functions including mitochondrial regulation and modulation of the transforming growth factor-beta (TGF-β) pathway, impacting cell growth, differentiation, and extracellular matrix formation. Rare loss-of-function variants in SLC2A10 cause arterial tortuosity syndrome (ATS), characterized by excessively long and tortuous arteries and connective tissue abnormalities, likely due to deficient mitochondrial ascorbic acid transport impairing collagen and elastin stability. As of now, SLC2A10 is not the target of any approved drugs, and diagnosis or monitoring of ATS mainly relies on genetic testing for pathogenic SLC2A10 mutations.

Other names

SLC2A10GLUT10Glucose transporter type 10facilitative glucose transporter GLUT10GLUT-10ATORSATSSolute carrier family 2 member 10

Not applicable for approved drugs; the proposed mechanism for future therapies would be modulation of glucose or dehydroascorbic acid transport. Modulation of TGF-β signaling through GLUT10 activity may impact connective tissue homeostasis.