Solute carrier family 22 member 13 (SLC22A13) (SLC22A13)

Solute carrier family 22 member 13 (SLC22A13), also known as Organic Anion Transporter 10 (OAT10), is a transmembrane protein primarily expressed in the apical membrane of renal proximal tubule cells [UniProt, NIH]. It functions as an anion exchanger, mediating the reabsorption of urate from the urine into the blood in exchange for organic anions such as nicotinate, lactate, and succinate [UniProt, Frontiers in Pharmacology]. Beyond its role in urate homeostasis, SLC22A13 is involved in the transport of orotate and the basolateral efflux of excitatory amino acids like aspartate and glutamate in the kidney [UniProt, NIH]. Genetic studies have linked SLC22A13 variants to serum urate levels and gout susceptibility, with dysfunctional mutations providing a protective effect against hyperuricemia [NIH, GeneCards]. Consequently, SLC22A13 is considered a significant therapeutic target for urate-lowering therapies [Frontiers in Pharmacology]. Several drugs, including the antihypertensive losartan and the uricosuric lesinurad, have been shown to inhibit SLC22A13, contributing to their clinical efficacy in lowering uric acid [Frontiers in Pharmacology, NIH]. Additionally, the protein has been investigated for its potential role in tumor suppression, where its overexpression can induce apoptosis in cancer cells by triggering endoplasmic reticulum stress [Wikipedia, NIH].

Other names

Organic anion transporter 10OAT10Organic cation transporter-like 3ORCTL3OCTL1OCTL3Solute carrier family 22 (organic anion/urate transporter), member 13

Inhibition of renal urate reabsorption via the apical membrane of proximal tubule cells, leading to increased urate excretion [Frontiers in Pharmacology, NIH]; Induction of tumor-specific apoptosis via endoplasmic reticulum stress and targeting of fatty acid metabolism [NIH, Wikipedia].