Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Carnitine/organic cation transporter type 2 (OCTN2)
- Target
- OCTN2
- Molecular classification
- Transporter, Solute Carrier
01
Overview
Carnitine/organic cation transporter type 2 (OCTN2) is a membrane protein encoded by the SLC22A5 gene. It mediates the active cellular uptake of carnitine and certain organic cations. OCTN2 is crucial for carnitine homeostasis, which is essential for mitochondrial beta-oxidation of fatty acids. Mutations in SLC22A5 cause primary systemic carnitine deficiency (SCD).
- Other names
- Organic cation/carnitine transporter 2High-affinity sodium-dependent carnitine cotransporterSolute carrier family 22 member 5 (SLC22A5)
02
Mechanism of action
Na+-dependent transport of L-carnitine; Na+-independent transport of organic cations
03
Biological functions
Carnitine transportOrganic cation transportNutrient absorptionRenal reabsorption
04
Disease associations
Primary systemic carnitine deficiencyMetabolic disorderCancer
05
Safety considerations
Drug-drug interactions affecting pharmacokinetics and toxicityNephrotoxicityAltered chemotherapy sensitivity/resistance
06
Interacting drugs
L-carnitine
7 more in the full profile.
07
Biomarkers
OCTN2 tumor expression (for oxaliplatin response in squamous cell carcinoma)
Beyond the preview
Go deeper on Carnitine/organic cation transporter type 2 (OCTN2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Carnitine/organic cation transporter type 2 (OCTN2).