Solute carrier family 6 member 10, pseudogene (SLC6A10P)

SLC6A10P, or solute carrier family 6 member 10, pseudogene, is a **pseudogene** located on chromosome 16 in humans[4][3]. It is a paralog of SLC6A8, which encodes the functional creatine transporter (CRTR)[1]. SLC6A10P does not encode a functional protein due to the presence of premature stop codons, although its promoter displays higher activity than the SLC6A8 promoter in experimental systems[4][1]. The gene is sometimes referred to as "Creatine transporter-2" or "CT-2", but there is no evidence that it produces a functional creatine transporter protein in humans[1][2]. There has been speculation about its possible regulatory or non-coding roles, such as acting as a target or buffer for regulatory RNAs, but it is not considered a bona fide therapeutic target, receptor, enzyme, or transporter[1]. Some expression is seen in testis, but its biological significance remains uncertain[1][2]. Key details: - SLC6A10P is a pseudogene, not a protein-coding gene[4][3][1]. - It is not a validated or actionable therapeutic target, nor does it have a direct role in disease, drug targeting, or protein-mediated biological functions[4][1]. - The common reference to "creatine transporter-2" is historical and potentially misleading, as no functional transporter protein is made from this locus in humans[1].

Other names

Creatine transporter-2CT-2SLC6A10Solute carrier family 6 member 10