Somatostatin receptor 1, Somatostatin receptor 3, Somatostatin receptor 5 (SSTR1, SSTR3, SSTR5)

Somatostatin receptor 1 (SSTR1), somatostatin receptor 3 (SSTR3), and somatostatin receptor 5 (SSTR5) are members of the somatostatin receptor family—G protein–coupled receptors that bind the endogenous peptide hormone somatostatin. These receptors mediate inhibitory signaling affecting hormone secretion, cell proliferation, and neuronal activity, with high expression in endocrine and neuroendocrine tissues. SSTRs serve as key therapeutic targets in neuroendocrine tumors and pituitary diseases, and are modulated by clinically available drugs including pasireotide, octreotide, and lanreotide. Structural studies reveal subtype-specific ligand binding and activation mechanisms, offering a framework for designing drugs with improved selectivity and efficacy

Other names

SS receptor 1somatostatin receptor type 1SS receptor 3somatostatin receptor type 3SS receptor 5somatostatin receptor type 5

Agonists bind to extracellular pockets, activating the receptor and causing conformational changes that engage G protein signaling, leading to downstream inhibition of adenylate cyclase and reduced secretion of target hormones (e.g., growth hormone)