SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 (SPOCK2)

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2, also known as SPOCK2 or Testican-2, is a member of the SPARC family of calcium-binding proteoglycans predominantly located in the extracellular matrix (ECM). This protein's structure consists of several domains, including a follistatin-like domain, a thyroglobulin type-1 domain with a characteristic CWCV motif, and an acidic C-terminal region with glycosaminoglycan-binding sites. SPOCK2 is involved in neurogenesis, ECM assembly, collagen binding, and cell-matrix adhesion; it is also linked to conditions such as cancer and bronchopulmonary dysplasia. Although structurally homologous to some signaling and adhesion molecules, SPOCK2 itself is not currently considered a classical therapeutic target, like a receptor or enzyme. No drugs or reliable biomarker roles are described for SPOCK2 to date.

Other names

Testican-2KIAA0275TICN2sparc/osteonectin, cwcv and kazal like domains proteoglycan 2SPARC/osteonectin, CWCV and Kazal-like domains proteoglycan 2Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2