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SPATA3 antisense RNA 1 (head to head) (SPATA3-AS1)
- Target
- SPATA3-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Other (does not fit into classical drug target families such as receptor, enzyme, transporter, or ion channel)
01
Overview
SPATA3 antisense RNA 1 (SPATA3-AS1) is a long non-coding antisense RNA transcribed head-to-head to the SPATA3 gene on chromosome 2[1][7]. The SPATA3 protein-coding gene is highly expressed in testis and important for spermatogenesis, cell proliferation, and sperm maturation[3]. By contrast, little evidence exists regarding the function, regulation, or disease relevance of the antisense transcript; its molecular role is not established, and it does not fit canonical drug target classifications. Multiple transcript and gene IDs correspond to this locus[1]. No drugs directly target SPATA3-AS1, and no biomarker or safety information is available. SPATA3-AS1 is best classified as a long non-coding antisense RNA, with uncertain function, lacking evidence for therapeutic targeting or disease involvement.
- Other names
- SPATA3-AS1SPATA3 antisense RNA 1 (head to head)ENSG00000238062ENST00000418330AC105344.2-007NONHSAT077325TCONS_00003509OTTHUMT00000333743.1XLOC_002517linc-GPR55AC105344.2
02
Biological functions
The specific biological functions of SPATA3-AS1 are not well-defined in current literature. It is transcribed antisense to SPATA3, which is involved in spermatogenesis and cell proliferation, but the functional role of SPATA3-AS1 itself remains unelucidated[1][3][5].Other (possible regulatory function, but experimental data are lacking).
03
Disease associations
Other (No direct associations with diseases have been described in available sources. However, the coding gene SPATA3 is implicated in male infertility and spermatogenesis disorders[3]. The disease relevance of the antisense RNA is unknown.)
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