Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)

Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) encodes the ubiquitous alpha-II spectrin protein, a cytoskeletal scaffolding protein, that forms heterodimers with beta-spectrins and is essential for plasma membrane stability, actin network organization, and subcellular architecture in non-erythroid cells[1][4][5][6]. SPTAN1 plays roles in cell adhesion, cell shape, cell cycle control, apoptosis, and DNA repair and is implicated in multiple cellular pathways, including cytoskeletal remodeling, signal transduction, and protein trafficking[1][3][4][5][6]. Mutations cause early infantile epileptic encephalopathy and various neurodevelopmental disorders; SPTAN1 and its proteolytic breakdown products are candidate biomarkers for neuronal injury, including traumatic brain injury, and are upregulated in diseases such as Guillain–Barré syndrome and congenital heart disease[3][4][5][6]. SPTAN1’s role in cancer includes effects on apoptosis, cell detachment, and metastasis, and altered expression is linked with both tumor suppression and promotion depending on context[1]. There are currently no approved drugs directly targeting SPTAN1.

Other names

Spectrin alpha chain, non-erythrocytic 1SPTAN1NEASSPTA2Alpha-II spectrinFodrin alpha chainSpectrin, non-erythroid alpha subunitalpha-fodrinDEE5DEVEPEIEE5HMN11HMND11SPG91epididymis secretory sperm binding proteinfodrin alpha chainspectrin, non-erythroid alpha chainspectrin, non-erythroid alpha subunitalpha-II spectrin