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Target intelligence / Profile preview
Spike Glycoprotein of SARS-CoV-2 (Ancestral Wuhan-Hu-1) (S protein)
- Target
- S protein
- Molecular classification
- Glycoprotein, Transmembrane protein, Fusion protein
01
Overview
The spike glycoprotein (S protein) of SARS-CoV-2 is a large, trimeric, class I fusion protein found on the surface of the virus. It is essential for viral entry into host cells and is the primary target for neutralizing antibodies and vaccine development. The ancestral reference sequence corresponds to the Wuhan-Hu-1 isolate. It mediates attachment/fusion with host cell membranes via ACE2 receptor.
- Other names
- SARS-CoV-2 Spike proteinSpike glycoproteinS proteinYP_009724390P0DTC2
02
Mechanism of action
Attachment to ACE2 receptor and subsequent membrane fusion
03
Biological functions
Viral entry into host cellsReceptor bindingMembrane fusion
04
Disease associations
InfectionCOVID-19
05
Interacting drugs
Neutralizing antibodies
1 more in the full profile.
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