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Target intelligence / Profile preview
Spike Glycoprotein Receptor Binding Domain (SARS-CoV-2) (RBD)
- Target
- RBD
- Molecular classification
- Glycoprotein, Viral protein, Receptor ligand
01
Overview
The SARS-CoV‑2 spike glycoprotein receptor binding domain (RBD) enables viral attachment to human cells via high-affinity interaction with ACE2. Its structure includes both conserved cores and variable motifs that are subject to immune pressure. As such, it remains central both to understanding COVID‑19 pathogenesis and developing effective countermeasures including vaccines and therapeutics.
- Other names
- SARS-CoV-2 Spike RBDSpike RBDReceptor Binding Domain
02
Mechanism of action
Binding to ACE2 receptor, blocking viral entry. Neutralization of virus through antibody binding.
03
Biological functions
Receptor bindingViral entryMembrane fusionImmune evasion
04
Disease associations
InfectionCOVID-19SARS-CoV-2 infection
05
Safety considerations
Antibody-dependent enhancement (ADE)Immune escape due to mutationsOff-target effects of therapeutics
06
Interacting drugs
Monoclonal antibodies (e.g., Sotrovimab, REGN-COV2)
3 more in the full profile.
07
Biomarkers
RBD-specific antibody titersACE2 binding affinity
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