Sprouty-related EVH1 domain-containing protein 1 mRNA 3' untranslated region (SPRED1 mRNA 3' UTR)

The SPRED1 mRNA 3' untranslated region (3' UTR) is a critical regulatory segment of the SPRED1 transcript that governs the stability and translation of the SPRED1 protein (NCBI Gene ID: 161742). SPRED1 functions as a potent negative regulator of the RAS/MAPK signaling pathway by inhibiting the activation of RAF (UniProt Q96CY2). The 3' UTR contains multiple binding sites for microRNAs, most notably miR-126, which suppresses SPRED1 expression to facilitate processes like angiogenesis and cell migration (Fish et al., 2008, Developmental Cell). Dysregulation of this region, often through microRNA overexpression, is linked to various cancers and cardiovascular conditions where SPRED1 levels are pathologically reduced (PubMed: 23536551). Consequently, the SPRED1 3' UTR is an emerging therapeutic target for RNA-based therapies, such as antagomirs or antisense oligonucleotides, designed to restore SPRED1 levels and normalize RAS signaling in disease states like Legius syndrome (Brems et al., 2007, Nature Genetics).

Other names

SPRED1 3' UTRSprouty-related EVH1 domain-containing protein 1 3' untranslated regionhfl-331 3' UTR

Modulation of SPRED1 protein expression by interfering with microRNA-mediated repression or mRNA degradation at the 3' UTR binding sites, thereby regulating the RAS/MAPK signaling cascade.