Sprouty RTK signaling antagonist 1 (SPRY1) mRNA 3' untranslated region (SPRY1 mRNA 3'UTR)

The Sprouty RTK signaling antagonist 1 (SPRY1) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the messenger RNA encoding the SPRY1 protein (UniProt Q9UJV9). This region contains highly conserved binding sites for various microRNAs, most notably miR-21, which post-transcriptionally represses SPRY1 expression (Thum et al., 2008, Nature). SPRY1 itself acts as a potent inhibitor of the Ras/MAPK signaling pathway, which is essential for regulating fibroblast activation and tissue remodeling (PubMed: 19043405). In pathological conditions such as cardiac or renal fibrosis, miR-21 is often upregulated, leading to the suppression of SPRY1 via its 3'UTR and subsequent over-activation of fibrotic pathways (Gomez et al., 2013, JCI). Therapeutic strategies, such as the use of anti-miR oligonucleotides like Lademirsen (RG-012), aim to block the interaction between miR-21 and the SPRY1 3'UTR to restore SPRY1 levels and mitigate disease progression (Regulus Therapeutics). Consequently, this 3'UTR serves as a pivotal molecular interface for modulating growth factor signaling in chronic inflammatory and fibrotic disorders.

Other names

Sprouty homolog 1 3'UTRSPRY1 3'-untranslated regionhSPRY1 3'UTRSprouty RTK signaling antagonist 1 3'UTR

MicroRNA-mediated translational repression and mRNA degradation; therapeutic intervention typically involves sequestering microRNAs (e.g., miR-21) to prevent their binding to this 3'UTR, thereby restoring SPRY1 protein levels.