SPT16 homolog, facilitates chromatin remodeling subunit pseudogene 1 (SUPT16HP1)

SUPT16HP1 is a pseudogene related to the SPT16 subunit of the Facilitates Chromatin Transcription (FACT) complex. Pseudogenes are non-coding sequences that resemble functional genes but do not produce active proteins. SUPT16HP1 does not encode an active protein and is not involved in chromatin remodeling or any therapeutic pathway. The functional chromatin remodeling factor is SPT16 (encoded by SUPT16H), which partners with SSRP1 to form the FACT complex—a key regulator of nucleosome dynamics, transcription, and implicated as a therapeutic target in cancer due to its high expression in tumors and essentiality for tumor cell survival[1][3][5]. Summary of core issue: SUPT16HP1 refers to a non-coding pseudogene. The protein-coding parent gene/protein (SPT16, encoded by SUPT16H) is biologically important and pharmacologically relevant, but the pseudogene itself is not a drug target, does not encode an active protein, and should not be considered a therapeutic target[1][3][5].

Other names

bcm670SUPT16HPsuppressor of Ty 16 homolog pseudogene 1

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