SPT20 homolog, SAGA complex component (SUPT20H)

SUPT20H encodes **SPT20 homolog, SAGA complex component**, a critical scaffold subunit of the human SAGA (Spt-Ada-Gcn5 acetyltransferase) coactivator complex, which regulates gene expression by interacting with enhancer-bound activators and modifying chromatin structure to enable transcription by RNA polymerase II[1][2][3]. SUPT20H is essential for the structural integrity and assembly of SAGA, forming the largest interface within the complex and acting as a clamp-like scaffold[1]. Besides its role in transcription regulation, SUPT20H is required for proper activation of MAP kinase pathways during gastrulation and autophagy, and it participates in positive regulation of gluconeogenesis and E-cadherin down-regulation[2]. Although no direct drugs target SUPT20H currently, the broader SAGA complex (containing SUPT20H) is implicated in certain cancers and neurodevelopmental diseases due to the functional importance of its subunits and their interfaces[1][2].\n- SUPT20H is not currently considered a standalone therapeutic target but is functionally critical within the multi-subunit SAGA complex, whose dysfunction can be pathogenic.\n- No known drugs directly target SUPT20H; targeted interventions are currently focused on the broader SAGA complex or interacting proteins such as TRRAP.\n- There are no described SUPT20H-specific biomarkers for clinical use.

Other names

FAM48AC13orf19SPT20FP757P38IPp38IPp38-interacting proteinsuppressor of Ty 20 homologtranscription factor SPT20 homologfamily with sequence similarity 48 member Aprotein FAM48Atumor rejection antigen