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Target intelligence / Profile preview
Squalene-based Oil-in-Water Emulsion (MF59) (MF59)
- Target
- MF59
- Molecular classification
- Adjuvant, Emulsion
01
Overview
MF59 is a squalene-based oil-in-water emulsion adjuvant widely used in human vaccines, particularly for influenza. It enhances both the magnitude and quality of immune responses to co-administered antigens by inducing chemokines and inflammatory cytokines, promoting danger signal release, and stimulating the differentiation of Mo-DCs. It is considered safe and well-tolerated in humans and enhances protective immunity against viral strains.
- Other names
- MF59 AdjuvantSqualene EmulsionOil-in-Water Emulsion Adjuvant
02
Mechanism of action
Enhances immune responses to co-administered antigens through chemokine/cytokine induction, danger signal release (ATP), and differentiation of monocyte-derived dendritic cells (Mo-DCs).
03
Biological functions
Immune StimulationAntigen DeliveryInflammationRecruitment of Immune CellsActivation of Immune Cells
04
Disease associations
Infectious DiseasesVaccination
05
Safety considerations
Local injection site reactions
06
Interacting drugs
Influenza Vaccines
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