Src, Abl, YES1

The proteins Src, Abl, and YES1 are members of the protein tyrosine kinase superfamily, specifically the Src family kinases (SFKs), with Abl representing a closely related kinase subfamily. These non-receptor tyrosine kinases regulate diverse cellular processes, including proliferation, differentiation, adhesion, migration, angiogenesis, and survival. Overactivation or gene amplification of these kinases is implicated in many cancers, where they can function as oncogenic drivers or mediators of resistance to targeted therapies. YES1 gene amplification, for example, is associated with acquired resistance to ALK and EGFR inhibitors in lung cancer and HER2-directed therapy in breast cancer, and dual SFK and primary driver inhibition can restore drug sensitivity. Therapeutic agents like dasatinib, imatinib, and bosutinib target these kinases and are widely used in cancer treatment, especially leukemia and various solid tumors

Other names

c-Srcpp60c-srcProto-oncogene c-Srcc-AblABL1Abelson tyrosine-protein kinase 1c-YesYES proto-oncogene 1

ATP-competitive inhibition of kinase activity; Blocking downstream oncogenic signaling pathways; Reversal of drug resistance by inhibiting YES1 upregulation; Inhibition of cell proliferation, survival, migration, and invasion