SRC kinase signaling inhibitor 1 mRNA 3'-untranslated region (SRCIN1 mRNA 3'-UTR)

The SRC kinase signaling inhibitor 1 (SRCIN1) mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the SRCIN1 transcript, which encodes the p140Cap protein (Source: UniProt Q9C0H9). This region contains multiple binding sites for microRNAs (miRNAs) that post-transcriptionally regulate the expression of SRCIN1, a known inhibitor of Src family kinases. In various malignancies, such as breast and gastric cancers, overexpression of specific miRNAs like miR-150 or miR-211 leads to the downregulation of SRCIN1 via its 3'-UTR, thereby promoting tumor cell proliferation, migration, and invasion (Source: PubMed 25633788, 28415714). Consequently, the SRCIN1 mRNA 3'-UTR serves as a significant focal point for therapeutic intervention, where antisense oligonucleotides or miRNA inhibitors can be used to restore SRCIN1 levels. Beyond oncology, this regulatory region plays a role in synaptic plasticity and neurological health by modulating p140Cap expression in the brain (Source: PubMed 23103810). Understanding the interaction between the 3'-UTR and its regulatory ligands is essential for developing targeted RNA-based therapies.

Other names

p140Cap mRNA 3'-UTRSNIP mRNA 3'-UTRSRC kinase signaling inhibitor 1 3'-UTRSRCIN1 3'-UTR

MicroRNA-mediated gene silencing through complementary binding to the 3'-UTR, leading to mRNA degradation or translational repression.