Staphylococcus aureus fibronectin-binding protein B (FnBPB) (FnBPB)

Staphylococcus aureus fibronectin-binding protein B (FnBPB) is a critical cell-wall-anchored surface protein belonging to the MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family. It plays a pivotal role in the pathogenesis of S. aureus by mediating bacterial attachment to host extracellular matrix components, specifically fibronectin, fibrinogen, and elastin [UniProt: P0C0S9]. Beyond simple adhesion, FnBPB facilitates the invasion of non-professional phagocytes, such as endothelial and epithelial cells, by triggering the integrin-mediated uptake of the bacteria [PubMed: 11585119]. This protein is highly implicated in serious clinical conditions, including infective endocarditis, osteomyelitis, and persistent wound infections, where it contributes to biofilm formation and immune evasion [PubMed: 24101602]. As a therapeutic target, FnBPB is being investigated for the development of anti-adhesion drugs and multi-component vaccines aimed at preventing the initial stages of infection [PubMed: 30244131]. Inhibiting FnBPB function could potentially reduce the severity of invasive staphylococcal diseases and overcome challenges associated with antibiotic resistance by neutralizing virulence rather than killing the bacteria directly.

Other names

Fibronectin-binding protein BFnBP-BfnbB

Inhibition of bacterial attachment to host extracellular matrix components and prevention of integrin-mediated host cell invasion.