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Target intelligence / Profile preview
Steroid 17,20 Lyase (CYP17A1)
- Target
- CYP17A1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Steroid 17,20 lyase, also known as Cytochrome P450 17A1 (CYP17A1), is a crucial enzyme in steroid hormone biosynthesis. It catalyzes two key reactions: the 17α-hydroxylation of pregnenolone and progesterone, and the subsequent cleavage of the C17–C20 bond. It is essential for the production of glucocorticoids, mineralocorticoids, and sex steroids. Mutations or deficiencies in CYP17A1 can lead to sexual infantilism, pseudohermaphroditism, adrenal hyperplasia, and hypertension. Pharmacological inhibition is used in prostate cancer treatment.
- Other names
- Cytochrome P450 17A117alpha-hydroxylase17,20-lyase
02
Mechanism of action
CYP17A1 inhibition
03
Biological functions
Steroid hormone biosynthesisAndrogen synthesisEstrogen synthesisGlucocorticoid synthesisMineralocorticoid synthesis
04
Disease associations
Congenital adrenal hyperplasiaSexual development disordersHypertensionProstate cancer
05
Safety considerations
Adrenal insufficiencyMineralocorticoid excessSexual dysfunction
06
Interacting drugs
Abiraterone acetate
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