Stomatin-like protein 2, mitochondrial (STOML2)

Stomatin-like protein 2, mitochondrial (STOML2) is a mitochondrial inner membrane protein that functions as an organizer of membrane microdomains by binding the phospholipid cardiolipin and recruiting prohibitin complexes. It plays a vital role in mitochondrial biogenesis, the assembly and stability of respiratory complexes, and the regulation of mitochondrial quality control pathways including modulation of the PARL/PINK1 mitophagy axis. STOML2 may also localize to the plasma membrane of activated T cells, where it enhances T cell receptor (TCR) signal transduction. Aberrant STOML2 expression is seen in multiple cancer types, where its levels can influence cell proliferation, mitochondrial dynamics, apoptotic resistance, and chemoresistance—making it a proposed biomarker and therapeutic target for certain tumors. No approved drugs currently target STOML2 directly, but research highlights its potential value in cancer therapy, particularly for overcoming chemoresistance through modulation of mitochondrial processes.

Other names

Stomatin-like protein 2, mitochondrialSTOML2SLP2HSPC108Paratarg-7SLP-2EPB72-like protein 2Paraprotein target 7EPB72-like 2stomatin (EPB72)-like 2

Potential future anti-cancer therapies under investigation aim to overexpress STOML2 to repress mitophagy and reduce chemoresistance to agents like gemcitabine