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Target intelligence / Profile preview
Streptococcus pneumoniae Capsular Polysaccharide (Conjugated) (Pn CPS (Conjugated))
- Target
- Pn CPS (Conjugated)
- Molecular classification
- Polysaccharide, Bacterial Surface Antigen, Vaccine Antigen
01
Overview
The Streptococcus pneumoniae capsular polysaccharide is a complex carbohydrate structure that forms the outermost layer of the bacterium, acting as a primary virulence factor by preventing phagocytosis. When conjugated to a carrier protein, it serves as an effective antigen in pneumococcal conjugate vaccines, inducing serotype-specific antibody production and subsequent opsonophagocytosis. However, the diversity of serotypes presents ongoing challenges and opportunities for vaccine development.
- Other names
- Pneumococcal Capsular Polysaccharide (Conjugated)S. pneumoniae CPS (Conjugated)Pneumococcal Conjugate Vaccine AntigenPrevnar 13/20 AntigenSynflorix Antigen
02
Mechanism of action
Induction of serotype-specific antibody production leading to opsonophagocytosis of Streptococcus pneumoniae.
03
Biological functions
Evasion of phagocytosisVirulence factorInduction of antibody response (when conjugated)Opsonization target (when conjugated)
04
Disease associations
PneumoniaMeningitisBacteremiaOtitis MediaInfection
05
Safety considerations
Serotype replacementLimited coverage of all serotypesInjection site reactionsHypersensitivity reactions
06
Interacting drugs
Prevnar 13
2 more in the full profile.
07
Biomarkers
Anti-capsular polysaccharide antibody titers
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