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Streptococcus pneumoniae Capsular Polysaccharides (Serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F)
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Bacterial Antigen
01
Overview
Streptococcus pneumoniae capsular polysaccharides (CPS) are high-molecular-weight carbohydrate polymers that form a capsule surrounding the bacterial cell. This capsule is the dominant surface structure of S. pneumoniae and is essential for its virulence. The CPS protects the bacterium from host immune responses by interfering with opsonophagocytic clearance mechanisms. There are over 98 recognized serotypes of S. pneumoniae based on differences in their capsular polysaccharide structures; each serotype elicits a distinct immunological response. The query focuses on serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, which are included in major multivalent pneumococcal conjugate vaccines.
- Other names
- Pneumococcal Capsular PolysaccharidesS. pneumoniae CPSSerotype-specific capsular polysaccharides
02
Mechanism of action
Induction of serotype-specific antibody responses via conjugate vaccines, promoting opsonophagocytosis and complement-mediated killing of S. pneumoniae.
03
Biological functions
Immune evasionVirulenceCapsule formationProtection against phagocytosisColonization
04
Disease associations
PneumoniaMeningitisBacteremiaOtitis mediaInvasive Pneumococcal Disease (IPD)Infection
05
Safety considerations
Hypersensitivity reactions to vaccine componentsLocal injection site reactionsPotential for serotype replacement after widespread vaccination
06
Interacting drugs
Prevnar13®
1 more in the full profile.
07
Biomarkers
Anti-capsular polysaccharide IgG antibody titersSerotype-specific antibody levels
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