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Target intelligence / Profile preview
Streptococcus pneumoniae Polysaccharide (Conjugated to CRM197) (PCV)
- Target
- PCV
- Molecular classification
- Polysaccharide, Protein Conjugate, Vaccine Antigen
01
Overview
Streptococcus pneumoniae polysaccharide conjugated to CRM197 is a vaccine antigen used in pneumococcal conjugate vaccines (PCVs). It consists of capsular polysaccharides from various serotypes of *Streptococcus pneumoniae*, chemically linked to CRM197, a non-toxic mutant of diphtheria toxin. This conjugation transforms the immune response from T-cell independent to T-cell dependent, resulting in higher antibody titers, improved immunological memory, and broader protection, particularly in infants and young children.
- Other names
- Pneumococcal Conjugate VaccinePCV7PCV10PCV13Prevnar®13Synflorix®Pneumosil®
02
Mechanism of action
Induces antibody production against *Streptococcus pneumoniae* capsular polysaccharides, preventing infection by opsonization and complement-mediated killing. Conjugation to CRM197 enhances T-cell dependent immune response.
03
Biological functions
Induction of humoral immunityB cell activationT cell activationAntibody productionImmunological memory
04
Disease associations
InfectionPneumococcal diseasePneumoniaMeningitisBacteremia
05
Safety considerations
Local injection site reactionsFeverIrritabilityRare: Hypersensitivity reactions
06
Interacting drugs
None (vaccine itself)
07
Biomarkers
Anti-capsular polysaccharide antibody titersOpsonophagocytic activity
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