Stromal vascular tissue (SVT) (SVT)

Stromal vascular tissue (SVT), also known as stromal vascular fraction (SVF), is a heterogeneous autologous cell population derived from adipose tissue through enzymatic or mechanical dissociation (Bora & Majumdar, 2017, PMID: 28611935). This complex mixture includes adipose-derived stem cells (ADSCs), endothelial progenitor cells, pericytes, fibroblasts, and various immune cells (Zuk et al., 2001, PMID: 11282033). SVT is not a single molecular target but rather a therapeutic modality used in regenerative medicine to promote tissue repair and modulate inflammation. Its therapeutic effects are mediated through paracrine signaling, where the cells secrete a variety of growth factors and cytokines, such as VEGF and HGF, to stimulate angiogenesis and reduce local tissue stress (Guo et al., 2016, PMID: 27034794). SVT is currently being investigated for a wide range of clinical applications, including the treatment of osteoarthritis, chronic wounds, and ischemic cardiovascular diseases (Nguyen et al., 2016, PMID: 27462591). Because it is a cell-based therapy composed of multiple cell types, its efficacy depends on the collective action of the population rather than the modulation of a specific receptor or enzyme.

Other names

Stromal vascular fractionSVFAdipose-derived stromal vascular fractionAdipose-derived regenerative cellsADRCs

SVT functions through the synergistic action of its constituent cells, which secrete pro-angiogenic and anti-inflammatory cytokines (paracrine effect) and can differentiate into specific cell lineages to replace damaged tissue (Bora & Majumdar, 2017).