Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA)
- Target
- SDHA
- Molecular classification
- Enzyme, Flavoprotein, Mitochondrial protein
01
Overview
The succinate dehydrogenase [ubiquinone] flavoprotein subunit (SDHA) is a key component of the succinate dehydrogenase (SDH) complex (Complex II) located in the mitochondrial inner membrane. SDHA catalyzes the oxidation of succinate to fumarate in the citric acid cycle, transferring electrons to ubiquinone and linking the citric acid cycle with the electron transport chain. SDHA contains a covalently bound FAD cofactor essential for catalytic function. Mutations or dysfunction of SDHA is linked with metabolic disorders and cancer.
- Other names
- Flavoprotein subunit of complex IIFpMalate dehydrogenase [quinone] flavoprotein subunitSDH2SDHF
02
Mechanism of action
Inhibition of succinate dehydrogenase activity.
03
Biological functions
Citric acid cycleMitochondrial electron transportElectron transfer activitySuccinate dehydrogenase (quinone) activityOxidation-reduction process
04
Disease associations
CancerMetabolic disorders
05
Safety considerations
Potential for metabolic imbalances upon inhibition.Tumor suppressor role considerations.
Beyond the preview
Go deeper on Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA).