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Target intelligence / Profile preview
Superoxide Dismutase [Cu-Zn] (SOD1)
- Target
- SOD1
- Molecular classification
- Enzyme, Antioxidant enzyme, Metalloprotein
01
Overview
Superoxide dismutase [Cu-Zn] (SOD1) is a critical antioxidant enzyme that catalyzes the dismutation of superoxide radicals into molecular oxygen and hydrogen peroxide, protecting cells from oxidative damage. Mutations in SOD1 are causative for some forms of familial amyotrophic lateral sclerosis (fALS). Overexpression has also been observed in various cancers.
- Other names
- Superoxide dismutase 1Cu/Zn SODhSOD1
02
Mechanism of action
Catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide.
03
Biological functions
Antioxidant defenseSuperoxide radical scavengingRegulation of apoptosisRedox homeostasisCell survival
04
Disease associations
Amyotrophic Lateral Sclerosis (ALS)Neurodegenerative diseaseOxidative stress-related diseasesCancerParkinson's disease
05
Safety considerations
Gain-of-function toxicity of some SOD1 mutants in ALSPotential for altered reactivity toward hydrogen peroxide leading to hydroxyl radical formationOverexpression in cancer may promote tumor survival
06
Biomarkers
SOD1 expression levels in cancerSOD1 mutations in fALSSOD1 activity as a measure of oxidative stress
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