Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Manganese Superoxide Dismutase (MnSOD)
- Target
- MnSOD
- Molecular classification
- Enzyme, Antioxidant enzyme, Metalloprotein, Oxidoreductase
01
Overview
Manganese superoxide dismutase (MnSOD), or SOD2, is a mitochondrial antioxidant enzyme that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and oxygen. It plays a crucial role in protecting cells from oxidative damage and maintaining redox balance. Dysregulation of MnSOD is implicated in various diseases, including cancer, neurodegeneration, and cardiovascular disorders. MnSOD expression and activity are regulated at multiple levels, including transcriptional control and post-translational modifications.
- Other names
- SOD2Superoxide Dismutase 2, Mitochondrial
02
Mechanism of action
Catalyzes the dismutation of superoxide anion radicals into hydrogen peroxide and molecular oxygen, reducing oxidative stress.
03
Biological functions
Antioxidant defenseRedox homeostasisSuperoxide radical scavengingRegulation of apoptosisProtection against oxidative stress
04
Disease associations
Cancer (progression and suppression)Neurodegenerative diseaseCardiovascular diseaseDiabetes complicationsAging-related pathologiesInflammation
05
Safety considerations
Potential for paradoxical effects in cancer (tumor-promoting in some contexts)Off-target effects of MnSOD modulatorsComplexity of redox regulation; potential for unintended consequences
06
Biomarkers
MnSOD expression levelsOxidative stress markers (e.g., malondialdehyde)Mitochondrial dysfunction markers
Beyond the preview
Go deeper on Manganese Superoxide Dismutase (MnSOD).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Manganese Superoxide Dismutase (MnSOD).