Suppressor of G2 allele of Skp1 homolog (Sgt1) (Sgt1)

Suppressor of G2 allele of Skp1 homolog (Sgt1) is a conserved cochaperone protein that interacts with Hsp90 and is involved in multiple cellular processes, including the stabilization of several oncoproteins, Cullin E3 ubiquitin ligase activity, assembly and maintenance of kinetochores during mitosis, and centrosome maturation[3][5][7]. Sgt1 overexpression is associated with cancer and is essential for cell viability in certain tumor contexts, making it a potential—though currently not clinically targeted—therapeutic target[3]. Knockdown of Sgt1 impairs tumor growth by destabilizing oncoproteins required for cancer cell survival. Sgt1 is not a receptor, enzyme, or transporter, but rather a regulatory protein critical for protein complex assembly and cell cycle progression[3][7]. Notably, in humans, 'ENSG00000271251' is annotated as a pseudogene (i.e., not encoding a functional protein), so for drug discovery and biomolecular targeting, the true functional gene is SUGT1 (ENSG00000119718)[7]. Thus, information above relates to the protein-coding SUGT1, not the pseudogene designated by ENSG00000271251, and this Ensembl identifier is likely **incorrect** for an active therapeutic target.

Other names

Suppressor of G2 allele of SKP1 (S. cerevisiae) homologSUGT1SGT1 homologSuppressor of G2 allele of SKP1 pseudogeneENSG00000271251 (Ensembl gene ID, but see notes below)SUGT1 (functional gene)ENSG00000119718 (functional gene)

Not directly targeted by any approved drugs; modulation of protein-protein interactions within Hsp90 chaperone complexes