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SYS1-DBNDD2 readthrough (non-protein coding) (SYS1-DBNDD2)
- Target
- SYS1-DBNDD2
- Molecular classification
- Long noncoding RNA (lncRNA), Readthrough transcript, Other
01
Overview
SYS1-DBNDD2 is a long noncoding RNA produced by readthrough transcription between the SYS1 Golgi-localized integral membrane protein homolog gene and the dysbindin domain containing 2 (DBNDD2) gene on chromosome 20. The transcript contains exons from both parental genes but undergoes nonsense-mediated decay, making it non-protein coding and generally considered non-functional in classical protein-coding gene terms[1][7]. Some limited evidence suggests ncRNA readthroughs can modulate cellular responses, e.g., inflammatory or phagocytic activity in macrophages[3], but there is no evidence that SYS1-DBNDD2 serves as a biomarker, disease driver, or druggable protein target.
- Other names
- SYS1-DBNDD2SYS1-DBNDD2 readthroughC20orf169-DBNDD2C20orf169-DBNDD2 readthrough (non-protein coding)
02
Mechanism of action
None reported for drugs, as it is not a protein target
03
Biological functions
Regulatory noncoding RNA (may modulate inflammatory or phagocytic response of alveolar macrophages)Other
04
Disease associations
OtherNo direct link to specific diseases reported in core sources
05
Safety considerations
None reported due to lack of therapeutic relevance
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