T-cell immunoglobulin and mucin domain-containing protein 1 (TIM-1) (TIM-1)

T-cell immunoglobulin and mucin domain-containing protein 1 (TIM-1), also known as HAVCR1 or KIM-1, is a type I transmembrane glycoprotein that serves as the primary receptor for H-ferritin in oligodendrocytes (Todorich et al., 2008). This interaction is essential for the uptake of iron, which serves as a critical cofactor for enzymes involved in the synthesis and maintenance of myelin within the central nervous system (Chiou et al., 2018). Beyond its neurobiological role, TIM-1 is a significant immune modulator expressed on T-cells, where it influences Th1/Th2 differentiation and serves as a marker for acute kidney injury (UniProt P48551). In pathological states, TIM-1 is implicated in neurodegenerative diseases like Multiple Sclerosis due to its role in myelination, and it also functions as a receptor for several viruses, including Hepatitis A and Ebola (PubMed: 21921920). Therapeutic development targeting TIM-1 includes antibody-drug conjugates like CDX-014 for renal cell carcinoma and experimental approaches to promote remyelination in demyelinating disorders. The dual role of TIM-1 in iron homeostasis and immune signaling makes it a complex but promising target for both neurological and oncological applications.

Other names

Hepatitis A virus cellular receptor 1HAVCR1Kidney injury molecule 1KIM-1TIMD1CD365Oligodendrocyte ferritin receptorH-ferritin receptor

TIM-1 mediates the binding and clathrin-dependent endocytosis of H-ferritin to provide iron for oligodendrocyte metabolic processes and myelin production; it also acts as a co-stimulatory molecule for T-cell activation.