T cell-interacting, activating receptor on myeloid cells 1 (TARM1)

T cell-interacting, activating receptor on myeloid cells 1 (TARM1) is a member of the leukocyte immunoglobulin-like receptor family, characterized by two extracellular immunoglobulin-like domains, a transmembrane domain, and a short cytoplasmic tail without a canonical signaling motif. TARM1 associates with the Fc receptor γ-chain, enabling immunoreceptor tyrosine-based activation motif (ITAM)-dependent signaling. It is primarily expressed in granulocyte/monocyte lineages, notably in granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced dendritic cells, with expression upregulated during inflammatory conditions. TARM1 enhances dendritic cell maturation and antigen presentation by interacting with type II collagen, acts as a co-stimulatory molecule in myeloid cells, and is implicated in the promotion of inflammatory responses, including those seen in autoimmune arthritis. TARM1 deficiency impairs dendritic cell function and reduces disease severity in experimental autoimmune models, making it a candidate therapeutic target for modulating immune responses in autoimmune and inflammatory diseases

Other names

T-cell-interacting, activating receptor on myeloid cells protein 1OLT-2OSCAR-like transcript-2 proteinTARM1OLT-2 protein

Modulation of dendritic cell maturation and antigen-presenting capacity via ligand engagement (type II collagen) and FcRγ signaling\nPotential negative regulation of CD4+ T cell proliferation by binding unknown ligand on T cells